• Rat pheochromocytoma PC cells have been widely

  2020-10-14

  

  Rat pheochromocytoma PC12 cells have been widely used as a cell system to study intracellular signaling leading to neurite outgrowth. The advantages of using PC12 cells in the CHK studies are the fact that they naturally express the rat form of CHK and the observation that down-regulation of CHK fun

• br Conflict of interest br

  2020-10-13

  

  Conflict of interest Acknowledgements This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP: 2014/00926-3). Introduction The metacestodes of Taenia solium are the causative agent of cysticercosis, which mainly resides the skeletal muscles and the central n

• E is a classical initiator protein

  2020-10-13

  

  E1 is a classical initiator protein and, as such, plays several roles in the initiation and catalysis of viral DNA synthesis. E1 must first recognize a specific segment of the viral Tubacin known as the “origin of DNA replication”, or “ori” for short. For most PV types examined to date, the minimal

• Although many GPCR heteromers have been identified using

  2020-10-13

  

  Although many GPCR heteromers have been identified using heterologous cell lines, only very few fit all three criteria. This is mainly due to the difficulties to study these structures in native tissues because of the lack of sensitive and selective tools, not only capable of detecting in vivo evide

• The occurrence of three Ag NORs per metaphase and or

  2020-10-13

  

  The occurrence of three Ag-NORs per metaphase and/or a maximum of three nucleoli per nucleus in most of the varieties may be explained by chromosomal rearrangements or unequal crossing-over events that induce the deletion of the fourth active rDNA loci. Also, the chromosome pair that showed less int

• br DGAT protein interactions Although DGAT and

  2020-10-13

  

  DGAT-protein interactions Although DGAT1 and DGAT2 are membrane proteins of the ER, the ER contains within its extensive three-dimensional network different, unique structural and functional protein domains that arise from the non-uniformity imposed on it by the intracellular structures it intera

• Besides degrading cholesterol the cholesterol

  2020-10-13

  

  Besides degrading cholesterol, the cholesterol degradation pathway also offers a route to obtain useful starting materials for the production of steroid drugs and hormones. Indeed, steroids are among the most marketed pharmaceuticals with about 300 approved steroid drugs [15] and a worldwide market

• A range of therapies exists for the

  2020-10-13

  

  A range of therapies exists for the treatment of inflammation-driven diseases, which can be summarized as non-steroidal anti-inflammatory drugs (NSAIDs), corticoids and steroidal-related drugs (Ward et al., 2008). Despite of these notable successes, there are still major unmet medical needs in the t

• Recent data obtained with etifoxine suggest that facilitatio

  2020-10-13

  

  Recent data obtained with etifoxine suggest that facilitation of GABAergic inhibition may be also associated with an indirect mechanism implying activation of the peripheral benzodiazepine receptor with a subsequent increase in neurosteroid production (Schlichter et al., 2000, Verleye et al., 2005).

• As the COMT enzyme is primarily

  2020-10-12

  

  As the COMT enzyme is primarily related to prefrontal dopamine degradation (e.g., Yavich et al., 2007), the present study supports the notion that prefrontal dopamine modulates retention of fear extinction rather than within-session extinction (Abraham et al., 2014). Consistent with other studies we

• The contradictory effects exerted by metals were reviewed by

  2020-10-12

  

  The contradictory effects exerted by metals were reviewed by Nunes (2011) that stated that the concentration and the species of metal can cause specific effects in ChE activity. Being environmentally exposed, the organism can accumulate metals in tissues, increasing their concentrations. Some author

• br Materials and methods br Results br Discussion

  2020-10-12

  

  Materials and methods Results Discussion In this study, the N&B analysis showed new evidence regarding the proportion and the oligomerization state of the AT1 and the ETA receptors near or on the plasma membrane. Althought, preliminary studies suggest that the AT1 and the ETA receptors occu

• In most cases the ligand affinity between

  2020-10-12

  

  In most cases, the ligand affinity between subtypes is similar, but their tissue distribution is different. In the case of the estrogen receptors (ER), two subtypes (ERα and ERβ) exist (Kuiper et al., 1996) and ERβ has several isoforms, designated ERβ1–5 (Moore et al., 1998) or ERβcx (Ogawa et al.,

• br Conclusions br Conflicts of interest br Research

  2020-10-12

  

  Conclusions Conflicts of interest Research funding This work was financially supported by Shanghai Committee of Science and Technology (No. 16431903800). Main Text Developmental processes make usage of a surprisingly limited number of morphogens and signaling components to control a ple

• It has been reported that Eph Ephrin are involved

  2020-10-12

  

  It has been reported that Eph/Ephrin are involved in the regulation of the tumor angiogenesis [10], [11], [12]. The distinct and specific involvement of Trelagliptin and veins in tumor angiogenesis is unclear. EphrinB2 is expressed in arteries and its receptor EphB4 is expressed in veins; these mole

15417 records 753/1028 page Previous Next First page 上5页 751752753754755 下5页 Last page