• 2-Deoxyadenosine 5-diphosphate br Experimental section br Re

  2022-08-10

  

  Experimental section Results and discussion Conclusions To summarize, the act of conjugating a ASC ligands to a Ru(II) polypyridyl subunits resulted in a class of excellent DNA binders. A comparison of the DNA binding abilities of the free ASC ligand and the complexes, has revealed that the

• br Experimental br Results and discussions br Conclusion

  2022-08-10

  

  Experimental Results and discussions Conclusion Notes Introduction The noncanonical DNA structures that is, i-motif [[1], [2], [3], [4], [5], [6], [7], [8], [9]] and G-quadruplex [[10], [11], [12], [13], [14]] have recently been carefully studied using either experimental or computati

• Magtanong et al observed that caspase dependent apoptotic li

  2022-08-10

  

  Magtanong et al. (2019) observed that caspase-dependent apoptotic lipotoxicity of saturated fatty acids is suppressed by exogenous MUFAs. This may explain the ability of MUFAs to prevent atherosclerosis, in contrast to the pathogenicity of saturated fatty acids. Moreover, MUFAs may promote while PUF

• Membrane based integrative treatment processes emerge

  2022-08-09

  

  Membrane based integrative treatment processes emerge as potential solution compared to the conventional techniques. Gisi et al. (2009) presented a treatment scheme for tannery wastewater consisting of a biological pre-treatment and then a polymer as coagulant followed by reverse 7340 with a plane

• Renal disease is characterized by aberrant fibrotic remodeli

  2022-08-09

  

  Renal disease is characterized by aberrant fibrotic remodeling of renal tissue, elevated apoptosis in kidney tissue, and eventual organ failure. In addition, patients with renal disease are more likely to suffer from systemic hypertension due to oxidative damage (reviewed in Ref. [18]). Treatment of

• Amelogenesis is a complicated process as described above

  2022-08-09

  

  Amelogenesis is a complicated process, as described above, and for the last several decades, various animal and human studies have used molecular genetics to identify a number of signaling molecules and gene networks that act at specific stages of the ameloblast life cycle and regulate its patternin

• Recently it was found that hypoxia results in the phosphoryl

  2022-08-09

  

  Recently, it was found that hypoxia results in the phosphorylation of β-catenin at Y654 in a Src-dependent manner (Xi et al., 2013). All β-catenin phosphorylated at this residue was found complexed with Hif1α and it was demonstrated that this β-catenin phosphorylation was required for Src to promote

• br Funding This work was partially supported by

  2022-08-09

  

  Funding This work was partially supported by the National Institute on Alcohol Abuse and Alcoholism, award R00AA021264, startup funds from the Department of Immunology, Herbert Wertheim College of Medicine, and the Office of Research and Economic Development at FIU, and pilot funds from Dr. Werth

• The hypothesis that genes involved in type diabetes

  2022-08-09

  

  The hypothesis that genes involved in type 2 diabetes evolved under changing selective pressures and may carry the signature of natural selection motivated us to describe patterns of sequence variation at CAPN10 and GPR35 in human populations. An initial population genetics study reported an unusual

• TGR is a class A GPCR transducing signal through Gs

  2022-08-09

  

  TGR5 is a class A GPCR, transducing signal through Gs-protein mediated cAMP accumulation, and was recently reclassified as the founder member of the bile–acid receptor subclass of GPCRs [22]. The cAMP-mediated signaling of TGR5 activation has been implicated in a range of cellular physiological acti

• br Characterization and regional localization of Glu transpo

  2022-08-09

  

  Characterization and regional localization of Glu transporters Molecular studies led to the description of five subtypes of plasma membrane Glu transporters termed in accordance to their human or rodent origin (Kanai and Hediger, 1992, Pines et al., 1992, Storck et al., 1992). In humans, these t

• A number of experimental data

  2022-08-09

  

  A number of experimental data declare a tight interdependence between the pathological changes of glutamate transport in cox inhibitor and consequent alterations in glutamate transport and activity/expression of glutamate metabolizing enzymes in platelets (Aliprandi et al., 2005, Behari and Shrivas

• Genetic disruption or pharmacologic inhibition of the hepati

  2022-08-09

  

  Genetic disruption or pharmacologic inhibition of the hepatic glucagon pathway has invariably been shown to increase pancreatic α cell mass. This has been observed in glucagon receptor (GCGR) knockout (Gcgr−/−) mice (Gelling et al., 2003), glucagon knockout mice (Hayashi et al., 2009), prohormone co

• Murine models of sickle disease have been valuable tools in

  2022-08-09

  

  Murine models of sickle disease have been valuable tools in the study of human SCD pathogenesis [15], [16], and will continue to be central to development of novel approaches to disease treatment. The SAD mouse model of sickle disease is particularly remarkable for its erythrocyte dehydration phenot

• LPCs have been previously described

  2022-08-08

  

  LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al

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